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Certain health conditions, such as pernicious anemia or specific gastrointestinal disorders that affect B12 absorption, may require even longer-term or lifelong monthly injections

Overall, 21 and 16 treatment-emergent adverse events (TEAEs) were reported in 11 and 9 participants in the renal and hepatic studies, respectively

Of note is also that the supplementation with folic acid at doses higher than 1000 g/d was negatively associated with global verbal scores in children (Reference Valera-Gran, Navarrete-Muoz and Garcia de la Hera121)