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Side effects can include dizziness, fatigue, and nausea

Lancet 390 , 2 (2017)

Spatialtemporal trends in global childhood overweight and obesity from 1975 to 2030: a weight mean center and projection analysis of 191 countries

This may be a chance finding as the group who had combination therapy had similar changes in kidney functional parameters to the monotherapy groups, but this needs further study