glp-1 release is released from the small intestine after meal ingestion and Glucagon-like peptide-1 - Wikipedia

They are often more noticeable during treatment initiation and dose escalation, then may decrease as treatment continues

Dose management: Follow your physician prescribed semaglutide dose escalation schedule

Patients can use either side of the abdomen, providing multiple rotation options

Semaglutide on the other hand displays limited efficacy in crossing the BBB, but despite this fact it was proven to access the brainstem, septal nucleus and hypothalamus [42]

Metabolic and hormonal changes after laparoscopic roux-en-Y gastric bypass and sleeve gastrectomy: a randomized, prospective trial

In preclinical studies, GIPR/GLP-1R co-agonism produces less nauseating effects compared to GLP-1R agonism alone as measured by kaolin intake in mice and rats and emetic events in musk shrews (69)