Neptun showed an increased expression of glutathione transferase StGSTF2 and a general activity of GST, corresponding with an increase in the GSSG form and indicating involvement in the resistance reaction
ACSL4 catalyzes the reaction of PUFAs to polyunsaturated fatty acid-coenzyme A (PUFA-CoA), and then the PUFA-CoA undergoes esterification by lysophosphatidylcholine acyltransferase 3 (LPCAT3) to become polyunsaturated fatty acid-phospholipids (PUFA-PLs), which are then oxidized by reactive oxygen species (ROS) to cytotoxic phospholipid hydroperoxides (PL-OOH), leading to cell death through membrane modification (Liu et al., 2025
Excess inflammation is a well-known contributor to aging, as it can damage tissues and organs over time
[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., Yamamoto M
A.GullnerG.Clemente-MorenoM
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