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We also extended the manuscript to show that the durable depolarization of POMC neurons in response to GLP1R agonists requires PKA and L-type calcium channels, showing a likely mechanism of action for these drugs in appetite-regulatory human neurons

Ihaka, R

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In the SURMOUNT-1 trial (JAMA, 2022), participants on 5 mg weekly lost an average of ~15% of body weight over 72 weeks, compared to 2023% at higher doses