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Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1(G93A) mice model

Models for age-related diseases and show reductions in NAD + pools

However, unexpectedly, K87pAcF showed the lowest stability among all the variants with the Tm value of 44.4 C, although it was predicted to be more stable than the wild type

Kuratsune H

In summary, we highlight the importance of PSPH genetic alterations in GBM in promoting tumor aggressiveness and immunosuppression, which could be effectively targeted by a novel combinatorial therapeutic strategy of sertraline plus chloroquine

2015 (6), CD000219