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The NEJM study now follows 2539 obese people, 1032 also diagnosed with prediabetes in a placebo-controlled trial of 176 weeks active treatment, followed by 17 week non-treatment period

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Hypersensitivity reactions were also observed in a small percentage of subjects, affecting approximately 2-4% of participants in most studies [37]

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So to understand what is likely in those vials, you have to look at the one GLP-1 the scientists have tested, and extrapolate down from the easy case to the hard one