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Beyond glomerular damage, tubular atrophy and tubulointerstitial inflammation have also been demonstrated, while vascular lesions include arterial hyalinosis [16]

Compared to chow feeding, high-fat feeding for 35 weeks resulted in substantial rearrangement of the gut microbiota reflected by reduced bacterial community richness and diversity accompanied by highly consistent changes in the abundance of major bacterial divisions, dominated by phylum-level taxonomic shifts in Firmicutes , Bacteroidetes , Proteobacteria and Actinobacteria