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Pregnancy, Contraception and Breastfeeding Guidance GLP-1 medicines are not recommended during pregnancy or while trying to conceive due to insufficient safety evidence

The glutamic-acid substitution sterically prevents binding to IGF-binding proteins (IGFBPs), leaving a far larger fraction of the peptide free to engage the IGF-1 receptor (IGF-1R)

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10.1016/j.expneurol.2012.09.019 83 SchonH

Early-phase samples showed elevated glycolytic intermediatesincluding glucose and lactic acidreflecting high metabolic demand, accompanied by decreased TCA cycle intermediates such as glutamic acid, citric acid, and related carbon-flux metabolites

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