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In this study, metformin was demonstrated to significantly inhibit oxidative phosphorylation and enhance glycolytic rates in both HCT116 and SW837 cells, supporting it as an ETC inhibitor in CRC

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In animal studies, Janus kinase 1/2 inhibitors and Brutons tyrosine kinase inhibitors, other investigational agents for COVID-19 treatment 199 , improved glycaemia 200,201 and insulitis 200 and impaired the levels of anti-insulin B lymphocytes 202 and insulin antibodies 203 , which might have protective roles in T1DM