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The first GIP receptor antagonist was introduced in 1986 ( Figure 3 ), and in recent years, the truncated and deactivated form of GIP, GIP(3-30)NH 2 , has proven to be a potent and specific GIP receptor antagonist in humans in high concentrations, and suitable for studies of endogenous GIP physiology and pathophysiology (14) ( Table 1 )

7 Therapeutic implications and future directions At present, there is no curative or approved disease-specific treatment for ME/CFS, and clinical management remains largely supportive, with the primary goals of symptom relief and functional maintenance

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Ipamorelin: The Selective GH Secretagogue Ipamorelin is a pentapeptide and selective ghrelin receptor agonist (GHS-R1a)