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Absolute Contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) : The boxed warning specifically contraindicates tirzepatide in patients with a personal or family history of MTC due to the theoretical risk observed in animal studies

Dosing regimens vary by product and should be adjusted in patients with kidney impairment

Safety & Key Considerations Common GI adverse effects (class-related) Important risks: pancreatitis, AKI, gallbladder disease, hypoglycemia Boxed warning: thyroid C-cell tumors Contraindicated in MTC and MEN2 Clinical Takeaways Do not combine with other GLP-1 receptor agonists Represents a major shift toward non-injectable incretin therapy Likely to compete with agents like Semaglutide and Tirzepatide May significantly expand real-world uptake, especially in patients hesitant about injections Big Picture This isnt just a new drug it signals a paradigm shift

But Semaglutide GLP-1 is part of a new generation of highly effective obesity medications based on hormones

Hurst is president and CEO of the Retailers Association of Massachusetts

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