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There are no guarantees that orforglipron will be approved or make it to market on the anticipated timeline

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Takeda is supporting the BLA with data from the pivotal VISIBLE 2 Phase III trial, in which 409 adult patients experienced a clinical responsedefined as a decrease of 70 points or more in Crohns Disease Activity Index (CDAI) score from baselinefollowing two doses of open-label IV Entyvio

It is often categorized with the newer class of dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists

However, these uncontrolled observations require validation through prospective, controlled clinical trials before establishing standard treatment durations for specific clinical indications

Klauder JV, Meerman H