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Alternatively, whole blood may not be the appropriate cell type to detect changes in SMN expression, or such changes may be too small to be detected by relative quantification that relies on endogenous controls to normalize data

[11] Annually: Left wrist X-ray for bone age determination using the Greulich-Pyle atlas

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This tool was born out of Ros history of fighting for patients, including its efforts to simplify insurance navigation and approvals, helping patients maximize treatment access and get the best possible coverage

The vial itself is stored in the refrigerator and used over multiple weeks depending on the concentration and your dose

Aches typically start around week 4, peak at month 2-3 during the 7.5mg dose transition, and 90% of cases resolve by month 4 with proper hydration and electrolyte management