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Finally, the amino acid transporter SLC38A5 was also dramatically increased in cells of GCGR-KO mice

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With respect to uric acid excretion, the kidneys are the major regulatory organ, and renal impairment remains the most frequent underlying cause of reduced urate clearance ( Serum uric acid concentrations above 6.8 mg/dL exceed physiological solubility and enter a supersaturated state ( Figure 1 )

doi: 10.1002/advs.202301635 [DOI] [PMC free article] [PubMed] [Google Scholar] 244.Hosseinnejad A, Ludwig N, Wienkamp AK, et al

In fact, earlier studies suggest that lactate supports myelination in vitro in the setting of glucose deprivation (Rinholm et al., 2011)