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The safety profile was broadly consistent with earlier retatrutide studies and the wider incretin drug class, with diarrhoea, nausea and constipation among the most common adverse events

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Semaglutide & Tirzepatide: The Future of Weight Loss Discover a new approach to weight loss with Semaglutide and Tirzepatide

Overall, GLP-1 therapies may help calm certain aspects of IBS, particularly pain signaling, but they are not currently a first-line treatment and likely need to be used selectively

Essler S, Dehne N, Brne B

For many, the toughest side effects are behind them, and the uncertainty of those early weeks has given way to a new rhythm