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Patients with AIH often have liver injury and are beyond the time frame for early medical intervention

As GLP-1R mRNA in the aortic tissue was below the level of quantification in both animal models, it seems likely that GLP-1Rs in other tissues, rather than direct action of liraglutide or semaglutide on the vascular bed, contribute to the mechanism of gene regulation

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FIGURE 1 The majority of lipids in the human lipidome are made from three types of hydrocarbon-based building blocks, including fatty acids, which are carboxylic acids with aliphatic chains of various lengths, sphingosine, which is an amino alcohol with an unsaturated aliphatic chain, and sterols, which are polycyclic compounds with a core made of three cyclohexane rings and one cyclopentane ring