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Similarly, to enhance the efficacy of chain-breaking antioxidants, new derivatives with reduced toxicity and improved effectiveness, such as novel synthetic variants, various conjugates, or nanoformulations, specifically targeted to active sites of oxidative stress and particular ROS need to be developed

Similarly, underdosing reduces the effect of the medication

TIMP-1 and TIMP-2 tissue inhibitors of metalloproteinases are upregulated, further tipping the balance toward matrix preservation

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Indeed, OCTN2 has been shown to transport TEA in a Na + -independent manner 15 , albeit much less efficiently than carnitine (0.2-3% transport rate relative to carnitine) 18,23