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Specifically, the organization of the electron transport chain (ETC) complexes and ATP synthase is within the portions of the IMM that form cristae (specialized folded domains of the IMM) such that the H + are not free to diffuse throughout the whole of the inner membrane space

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Peer review Peer review information Nature Medicine thanks Qiwei Li, Carel le Roux and Katherine Tuttle for their contribution to the peer review of this work