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La dose viene gradualmente aumentata per migliorare la tolleranza

Dasatinib + quercetin, the most studied senolytic combination, works through different anti-apoptotic pathways (SCAPs) and does not specifically target the FOXO4-p53 axis

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Importantly, FOXO4-DRI showed no significant toxicity or impact on viability and apoptosis in normal TM3 Leydig cells, where FOXO4 expression is typically low