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Liu F, Dong YY, Lei G, Zhou Y, Liu P, Dang YH

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Serine 1177 is located on the C-terminal reductase domain and when phosphorylated, enhances eNOS activity by facilitating electron flow from NADPH to the heme domain, contributing to NO production (Fulton et al., 1999

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The approval is based on data from the SOUL trial of 9,650 patients and showed a 14 % relative risk reduction in MACE for the 14 mg dose

Brenchley and Douek 2012)