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[50] However, it is important to note that fenfluramine, rimonabant and lorcaserin used very different molecular mechanisms (acting mainly on serotonin 2c receptors [51] in the hypothalamus [52] or CB1 receptors [53] ) from GLP1R, GIPR or GR agonists and likewise do not imply anything on the possible dangers of GLP1R, GIPR or GR agonists

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Because of the invasiveness and cost of PET, even if a good ligand is developed, it would take many years to implement such a program of research

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This early weight loss plays a pivotal role in long-term treatment success