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Many of these conditions are connected, almost like dominoes lined up in a row

Discordance between ex vivo potency and in vivo PK/PD has many potential causes, one of which, in the case of schistosomicidal agents, is the involvement of the host immune response

Pharmacotherapy 42 , 921928 (2022)

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Peptide-based medications may require specialized facilities, carefully controlled production environments, purification, sterile filling and extensive quality testing

GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )