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It is widely used in biochemical research as a selective, substrate-competitive inhibitor of nicotinamide N-methyltransferase (NNMT)

P., Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J

To minimize such unwanted events, we developed a standardized thawing procedure for frozen samples, with a small sample volume (150-200 L): thawing under strict cooling conditions (+0C to +2C) within 12-15 minutes in an ice-water bath, without agitation

doi: 10.1038/s41598-025-92868-y 74 PereiraAGEchaveJJorgeAOSNogueira-MarquesRNur YuksekEBarcielaPet al

Its getting depleted because of excessive usage

Consult your doctor for advice in such a situation