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Exosome formation increased after GPX4 inhibition, which contained prominin and TSG101, as well as ferritin, while blocking the export of exosomes resulted in the accumulation of iron, indicating that in the state of cellular oxidative stress, prominin 2 can promote the formation of iron-containing exosomes and transport intracellular iron to the extracellular space, thereby enhancing cell resistance to ferroptosis [75]

The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents

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