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In the case of epilepsy, impaired K + buffering, glutamate clearance, lipid accumulation and malfunctioning of the glutamate (GABA)-glutamine shuttle emerge as leading pathophysiological processes

Similarly, -synuclein oligomers intervene with organellar functions and interact with metal ions to cause oxidative stress 14

In contrast, no statistically significant difference in glutathione levels was found in the medial frontal cortex, a brain region more directly tied to executive function, emotional processing, and self-referential thinking, highlighting the importance of analyzing glutathiones role in depression on a region-specific basis

A potent antioxidant, it successfully defends against free radical damage like UV exposure and pollution

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