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OTC products cannot be tailored to these genetic differences, whereas prescription options allow providers to adjust dosing and formulation based on individual response patterns

GLP-1 medications can help manage type 2 diabetes and obesity, but they may cause short-term mild-to-moderate side effects such as nausea, vomiting, diarrhoea, constipation, bloating, and decreased appetite, particularly at the beginning of treatment

Patients with higher starting BMIs also tend to experience more pronounced metabolic adaptation after weight loss, making maintenance dosing or longer treatment courses more important for sustained results

However, due to its short circulating half-life, native GLP-1 is ill-suited for chronic therapy [14]

Up to 82% relative reduction in liver fat at 24 weeks

doi: 10.2174/157339508784325046 40 AschenSZampellJCElhadadSWeitmanEAndrade Brot DeMMehraraBJ