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Results A total of 267 dysregulated metabolites were identified in patients with MMA, including 185 upregulated and 82 downregulated metabolites

also designated SOD1)

Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA

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This is one proposed explanation for folic acid anxiety , worsening depression, obsessive thinking, insomnia or emotional flattening in susceptible undermethylators