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[35]have shown that adults consuming 510 g/day of shiitake mushrooms showed improved immunity, with increased proliferation of -T and NK-T cells and enhanced production of receptors for activation

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"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects

Wolf et al., 2021