Through the new blood vessel formation these peptides can increase blood flow to injured tissue, particularly tendons, which have an inadequate blood supply
"Accordingly, this product is an unapproved new drug." Three of the companies, Prime Sciences, Lovega, and Gram Peptides, were also cited for marketing bacteriostatic water used to dilute the medication
In clinical trials, 6-16% of participants discontinued retatrutide due to gastrointestinal adverse events (Jastreboff et al., NEJM, 2023)
Slow titration (increasing the dose gradually) reduces severity substantially (GI Tolerability Across SURMOUNT 1-4, DOM 2025)
Nat Rev Endocrinol 21 , 482494 (2025)
Research Applications Peptide & Protein Reconstitution Hospira Bacteriostatic Water is commonly used to reconstitute lyophilized peptides and proteins for in vitro and in vivo research experiments [1]