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The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

Mao XD, Hu CY, Zhu MC, Ou HL, Qian YL

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Specific Hairstyling Habits Habits like tight buns, heat use, and exposure to aggressive chemicals can damage hair and create traction alopecia

Less focus

109,110 Notably, the majority of the targets of the above-discussed transcription factors also show crucial effects in synaptic transmission and plasticity, which may explain why transcription and translation can modulate synaptic function in the aetiology of ASD