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Knockout of this gene in mouse and zebrafish models produces no substantial overt defect, though stress does amplify the differences

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So, exogenous GLP-1R agonists have been more recently considered as a good choice for treating patients with diabetes [29]

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Science 379:eadd1236

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Unexpectedly, activation of p21, ICAM1, or SRXN1 was not observed (Supplementary Figure S5), although DNA (Nassini et al., 2010), and Keap1 ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study (Tafazoli and OBrien, 2009)

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