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For preclinical research this matters, because it allows the release of growth hormone to be studied without parallel rises in stress hormones confounding the interpretation

Prolonged glucagon infusion does not affect energy expenditure in individuals with overweight/obesity: a randomized trial

(2019) 14:e0216825

Even if you eat healthily and exercise, you may invariably be short on specific nutrients due to poor food quality (soil and pesticides affect nutrient value), stress, or absorption issues

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The transmission of oral microbes to the gut further underscores this axis