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Adverse reactions and tolerability: Since they are administered via injection and affect gastric emptying (particularly in the case of shorter-acting agents), GLP-1 receptor agonists present some tolerability concerns
Semaglutide's gastrointestinal effects vary by product and dose: nausea (20-44%), vomiting (9-24%), and diarrhea (9-30%) according to FDA prescribing information
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Other common side effects of GLP-1 agonists: diarrhea or constipation abdominal pain belching, gas, or heartburn feeling bloated injection site reactions vomiting Your clinician will offer you tips for managing side effects , as well as share common contraindications (reasons to not take semaglutide), including a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia
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