Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time
Importantly, this implies that FSP1 may be essential not only in cancer resistance to ferroptosis but also in physiological contexts such as adipose tissue metabolism, where regulation of neutral lipid oxidation is critical for maintaining tissue homeostasis
[DOI] [PMC free article] [PubMed] [Google Scholar] 65.McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H, Acute Liver Failure Study Group Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome
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