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Moreover, sensitivity analysis suggested that the reported metabolic characteristics of obese adults and healthy infants in glucose metabolism could be associated with the metabolic features of those in drug metabolism

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Additionally, epigenomic profiling of the infrapatellar fat pad in OA patients has revealed genome-wide DNA methylation profiles, providing valuable insights into the epigenetic regulation of OA [103]

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In addition, spermine has been reported to promote the formation of an APOE + macrophage-like state with immunoregulatory features in mouse macrophage models (30), suggesting that the Arg1-polyamine axis may participate in shaping specific functional subsets

If CagriSema truly prevents the metabolic slowdown associated with weight loss, as the preclinical data suggests, it could produce more durable outcomes with less weight regain after treatment completion