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Iron deficiency in heart failure, an underdiagnosed and undertreated condition during hospitalization

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This increase is dependent on the upregulation of the membrane-bound tryptophan transporter SLC36A4 and intracellular IDO1 in macrophages during the degradation of apoptotic cells in phagolysosomes, which also results in increased levels of the tryptophan metabolite kynurenine (Kyn)

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Layer 2: The Secondary Patent Estate and the Thicket Once a CoM patent is filed, the IP teams work shifts to building a secondary patent estate designed to cover every commercially valuable attribute of the drug beyond the molecule itself

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