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Preclinical research indicates GHK-Cu may extend this phase, but equivalent human evidence is lacking

Design, synthesis, and evaluation of -phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of -glutamyl transpeptidase

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(HPA axis), Hypothalamicpituitaryadrenal axis

Roesel RA, Hommes FA, Samper L: Pyroglutamic aciduria (5-oxoprolinuria) without glutathione synthetase deficiency and with decreased pyroglutamate hydrolase activity