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[15] Anti-estrogens are clinically used in the treatment of breast cancer and to reduce the breast cancer incidence in high-risk women

A lot, it would seem

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The GLP-1R is a G-protein coupled receptor that has wide tissue expression, including in the brain, the wall of the portal vein near the hilus of the liver, and arteries and arterioles from various organs (kidney, heart, pancreas, and intestine) [18]