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It mimics three gut and pancreatic hormones GLP-1, GIP and glucagon and acts on the same biology that Mounjaro and Wegovy target
Knock-in mice were generated in which both serine residues were replaced by non-phosphorylatable alanine residues (ACC1-S79A and ACC2-S212A) [34]
All three available options, Mounjaro, Wegovy, and Saxenda, require a prescription following a proper medical assessment
The prudent approach is to restart at one step below your maintenance dose and hold for two weeks before returning to the target level
In this context, retatrutide, a new GIP/GLP-1/GCG RA administered once weekly, is currently under investigation for chronic weight management and associated complications [5,9,13]