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Opioids are not recommended for fibromyalgia because they do not target the processes involved in centralized sensitization, and their use may cause additional harm because of the risk of dependence, misuse, worsening of hyperalgesia, and other significant adverse effects

Lactate dehydrogenase (LDH) release, adenosine triphosphate (ATP) level, iron ion, and lipid peroxidation (LPO) content were detected by commercial kits