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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

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10.1021/acsnano.0c03080 Summary Keywords glutathione exhaustion, reduction-response, metal nanomaterials, TME regulation, cancer therapy Citation Liu P, Hao L, Liu M and Hu S (2023) Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy

Mitochondrial respiratory chain complex I and III are considered to be the main producers of ROS, the impairment of which contribute to mitochondrial ROS formation (Trumbeckaite et al., 2017

This rapid saturation is a stark contrast to standard oral glutathione, which often takes up to six months of high-dose supplementation to achieve similar systemic elevations