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These side effects often decrease over time as the body adjusts to the medication

95% CI, 2.893.11)

(2012, European Journal of Clinical Pharmacology) showed that after two weeks of berberine at 300mg three times daily, CYP2D6 activity dropped substantially (dextromethorphan metabolic ratio increased nine-fold), and midazolam concentrations rose 38 to 40% due to CYP3A4 inhibition