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Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy

Research showed you needed at least 10mg/day to maintain normal pre-pregnancy B6 levels, and even then some women had low levels

2007 Oct-Dec;113(4-5):234-58

At higher concentrations, it competes with the unfolding protein for water molecules, increasing the energy required for the protein to unfold and thereby keeping it in its active configuration