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The isoform that regulates the production of EPO is HIF-2

The trial therefore provides no conclusive evidence that early adjunct therapy with amantadine provides true protective effects against the development of LIDs as opposed to its well-known symptomatic efficacy [135]

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Suryantari et al., 2020), thereby it can inhibit the conversion of 13,4-dihydroxyphenylalanine to melanin (Tse, 2010) and further induce melanin necrosis, that can avoid the melanogenesis process