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Overall, the risks of bias were relatively low for the whole included trials (See Figure 5 )

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Subsequent Gene Ontology (GO) enrichment analysis delineated marked perturbations in key biological processes, including cellular processes (e.g., membrane integrity maintenance), metabolic reprogramming (particularly carbohydrate and lipid metabolism), cellular anatomical entity organization (notably gut epithelial junction complexes), catalytic activity modulation (encompassing oxidoreductases and hydrolases), and molecular binding dynamics (e.g., receptor-ligand interactions) (Figure 2G)

Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology