In elderly individuals, lower serum 25(OH)D levels are correlated with elevated C-reactive protein (CRP) and systemic inflammation, while VDR dysfunction is associated with impaired bone metabolism and aging-related phenotypes [77, 78]
GSH, an endogenous low-molecular-weight thiol-containing compound, plays an essential role in cellular redox reactions and protects cells from ROS 37
Thus, homology models for these two transporters, which are in the C-state, are also used in the analysis for comparison
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