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Endocrine-disrupting chemicals and thyroid function According to the Endocrine Society, Endocrine-disrupting chemicals (EDCs) are defined as a mixture of chemicals or an exogenous chemical that can interfere with any aspect of hormone action (88)

Kidney damage as a result of a disease or infection

And ultimately, vitamin C does best with antioxidant friends and other beneficial ingredients which dont take kindly to cold temps

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Nitric oxide reacts with intracellular glutathione and activates the for S-nitrosoglutathione as a bioactive intermediary hexose monophosphate shunt in human neutrophils: Evidence

This temperature range is not arbitrary