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The pivotal role of central dysfunctional, insulin-resistant adipose tissue to the evolution of advanced fibrosis in patients with T2D and NAFLD, beyond body mass index (BMI) or steatosis, has been well established [5]

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Notably, histologic fibrosis stage improved by 1 point in 24% of patients on resmetirom compared to 10% on placebo, a signal that is not commonly seen with weight-neutral agents in such a short timeframe [26]

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Many people regain the weight they lose if they stop taking the medication

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