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Mechanism and Impact: Semaglutide belongs to the GLP-1 receptor agonist class, which regulates blood sugar and appetite but now appears to also improve arterial and heart function
1 A few key points for clinicians: Short half-life (1012 min): This quick clearance supports physiologic GH pulses rather than continuous stimulation. Preserved feedback loops: IGF-1 and somatostatin feedback acts to keep GH levels within physiologic norms
A 2025 head-to-head study confirmed it: tirzepatide users lost 20.2% vs 13.7% for semaglutide
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